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While both compounds work through different mechanisms that theoretically could complement each other, the safety, efficacy, and optimal dosing of this combination remain completely unknown

The tradeoff is cost

Originally developed for T2D, these agents enhance insulin sensitivity by reducing insulin resistance, as demonstrated by significant declines in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) scores

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Rybelsus tablets and Ozempic tablets both contain semaglutide as the active ingredient, but are formulated differently, so are not interchangeable on a dose-per-dose basis