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While immunotherapy has revolutionized cancer treatment, its efficacy in osteosarcoma remains severely limited by an immunologically cold and profoundly immunosuppressive tumor microenvironment (TME)

64 The primary endpoint was neurocognitive improvement defined as a change in the global summary score of Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) at 8 weeks compared to baseline

Your provider will help determine the best administration method based on your preferences and comfort level

doi:10.1016/S0076-6879(05)01028-1 [PubMed][Crossref] 10

284 A similar phenomenon has been observed in Gln-dependent clear cell renal carcinoma (RCC), which competitively depletes environmental Gln, causing local Gln depletion and IL-23 release from tumor-infiltrating macrophages, which further activates Treg function to suppress tumor immunity