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Semaglutide (Ozempic and Wegovy) hits 1 target - the GLP1 receptor

Under oxidative stress, the transcription factor Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE)

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In the GCH1-BH4 pathway, BH4 functions as an antioxidant capable of trapping peroxidized lipid radicals, with GCH1 serving as the rate-limiting enzyme in BH4 biosynthesis

In 2025, Cigna announced that it would cap monthly out-of-pocket costs at $200 for Wegovy and Zepbound in an effort to convince more employer-sponsored health insurance plans to cover the drugs