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Regulating Satiety Pathways: In the hypothalamus, GLP-1 RAs stimulate neurons that promote satiety (POMC/CART neurons) and inhibit neurons that drive hunger (NPY/AgRP neurons), reducing food intake and enhancing fullness (Zheng et al., 2024)

Medication interactions can complicate the picture

It promotes healthy cell repair, boosts immune function, and supports liver health for essential recovery and anti-aging

Ipamorelin avoids this problem almost entirely

Retatrutide Clinical Evidence Context Retatrutide has the strongest evidence in obesity, with Phase 3 data now available in obesity without diabetes, obesity with knee osteoarthritis, and type 2 diabetes