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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management under the brand name Mounjaro and for chronic weight management as Zepbound
GLP1 receptor agonist use was shown to be associated with a reduction in the risk for progression to cirrhosis in patients with MASLD and diabetes, and who started the medication early in the course of their disease, 13 leading the FDA to approve semaglutide for this condition in August 2025
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Microbial metabolites such as short-chain-fatty-acids, bile acids, and amino acid derivatives serve as pivotal modulators of mitochondrial bioenergetics, oxidative stress management, and fissionfusion processes
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