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( Chen, 2015 ) Histamine is metabolized or cleared from the body via two enzymes, histamine methyltransferase (HNMT) and diamine oxidase (DAO)

Studies reported that some patients complained of anorexia and abdominal distension in the Korean herbal medicine group, but patients were able to tolerate these effects and symptoms were also resolved voluntarily

A recent 2022 study demonstrated that not only neurons but also glial cells rely on glutathione for homeostasis (12)

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However, the majority of the scientific literature remains preclinical, meaning most studies have been conducted in animal models rather than human clinical trials