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The activation of microglial cells by A deposition promotes the production of proinflammatory and cytotoxic factors, such as TNF-, IL-1, IL-6, interferon-gamma (IFN-), transforming beta growth factor (TGF-), chemokines and macrophage inflammatory protein (Yan et al., 2021)

Dai WL, et al

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SIPS can be caused by various factors including persistent exposure to cell stress, namely, oxidative stress or DNA-damaging mediators 28,29