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In all models, the following fixed covariates were entered: assigned treatment (investigational product or placebo), baseline measurement of the outcome of interest, visit (day 14 1 day or day 28 1 day), visit in interaction with treatment, period (period 1 or period 2), sex and, for MIDT outcomes, incentive level
Importantly, there were no dose-dependent signals for pancreatitis or thyroid C-cell tumors in the human data, though the standard rodent-derived thyroid risk noted on semaglutide and tirzepatide labels will presumably carry over to retatrutide's prescribing information pending further analysis
These findings suggest a different and specific metabolic profile, at least for one genetic subtype
In other words, Retatrutide preserved lean tissue about as well as its peers while removing more fat overall