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They work upstream of GH production, preserving the body's own pulsatile secretion pattern a meaningful mechanistic advantage over synthetic HGH

[1] [2] Maintaining adequate hydration, particularly during the titration period, can help prevent dehydration-related dark urine

It reflects a broader shift: patients are researching peptide therapy as a serious alternative to lifestyle-only approaches to stubborn visceral fat and metabolic decline

Patients who have constipation should stop taking the drug until their symptoms relieve

At the Marcus Institute, we believe that body composition, including muscle and fat, need to be carefully tracked during GLP-1 weight loss to ensure any significant muscle loss or loss of bone density can be quickly detected and addressed