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In contrast, integral membrane substrates with degrons present in TMDs or within cytoplasmic domains are recognized by HRD1 in an ER lectin-independent manner or by other ERAD E3 ubiquitin ligases equivalently or preferentially

[7] Bone mineral content in rats: A separate 12-week study reported increases in bone mineral content and bone size in young adult female rats

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Our approach provides a criterion for highlighting a pathway together with the entities it contains, for example its reported enzymes, to build a sub-pathway representation richer than the classical methods that rely solely on pathways and compounds