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Slashcheva, I A

Subsequent studies further revealed that both TNF- and LPS activate the c-Jun N-terminal kinase (JNK) pathway to phosphorylate IRS-1 at Ser307, which blocks PI3K/Akt signaling and consequently impairs glucose uptake (45)

to limit certain sensitive-data uses

The GLP-1R and GIPR pathways both converge on beta cell function through incretin signaling, and retatrutide provides a tool to study the amplified incretin response that occurs when both receptors are activated simultaneously

Histopathological findings revealed preservation of neural architecture, with reduced axonal degeneration, diminished neuronal loss, and limited formation of cystic cavities, suggesting an attenuation of secondary injury processes (12)