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The elongation and closure of the autophagosomal membrane are regulated by two ubiquitylation-like systems
In IDH1 mutant glioblastoma, BCAT1 is transcriptionally suppressed because of the hypermethylation of three CpGs in the promoter, and this is also the consequence of IDH1 mutation-induced 2-hydroxyglutarate (2-HG) (Tonjes et al., 2013)
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doi:10.1016/j.cofs.2016.02.002 [Elsevier] Hurrell R, Egli I
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