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In the last years, many trials failed to find a unique treatment for all HFpEF phenotypes, apart from sodium-glucose cotransporter 2 inhibitors

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44 Thus, apart from tumor thickness greater than 5 mm and the presence of lymphovascular invasion, many of the histologic prognostic parameters of cutaneous melanoma (i.e., Breslows classification and Clarks level of invasion) do not apply to oral melanoma