This is not a sign that the medication isn't working, and it is not a dietary mistake
As the use of these medications continues to grow, our findings provide important reassurance to patients and clinicians alike that these treatments can support both body and mind, investigator Toby Pillinger, PhD, clinical lecturer, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, London, England, told Medscape Medical News
By race or ethnicity, 84% of trial participants were white, 10% Hispanic or Latino, 8% Asian, 4% black and 3% other
These findings uncover a non-canonical mechanism of action for GLP-1 analogs, highlighting a specific microbiota-endocannabinoid metabolic pathway as a potential therapeutic target for depression.
The FDA approved the GLP-1 drug Ozempic to reduce the risk of chronic kidney disease (CKD) progression among those with type 2 diabetes and CKD in 2025