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Macrophages undergo metabolic switching during differentiation into inflammatory (M1) or anti-inflammatory (M2) phenotypes

A second propylamine residue from dcAdoMet is added to spermidine producing spermine by the enzyme spermine synthase encoded by the SMS gene (also known as SPMSY)

Most healthcare professionals view it as generally safe because it is an endogenous substancemeaning your body already makes it and expects it to be there