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Engineered as a synthetic peptide based on the native GIP sequence and modified for extended half-life via fatty acid conjugation, tirzepatide delivers glycemic control, profound weight loss, and cardiometabolic benefits

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Oral B12 supplementation (1,000-2,000 mcg daily sublingual methylcobalamin) can replicate the B12 component of MIC injections and is effective for most patients without malabsorption issues

Diabetes is characterized by chronic systemic hyperglycemia, which activates several secondary metabolic pathwayssuch as the polyol pathway, accumulation of AGE products, and protein kinase C (PKC) activationthat contribute to retinal and systemic vascular damage [67]

There were no accompanying side effects or complications reported