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Vitamin B12 deficiency

GGT allows the degradation of GSH and the recycling of its constituent amino acids, such as glutamic acid and cysteine, to generate new GSH (so called -glutamyl cycle)

doi: 10.1093/oxfordjournals.aje.a010141 253 AshiqueSKumarSHussainAMishraNGargAGowdaBHJet al

We found that APR-017 or LCS3 treatment induced an increased level of ROS and a decreased level of GSH (presented as the ratio of GSH to oxidized form, GSSG) in VRK2-KO cells, but not VRK2-WT cells (Fig

"Integrative bioinformatics and experimental analysis revealed TEAD as novel prognostic target for hepatocellular carcinoma and its roles in ferroptosis regulation." Aging (Albany NY)