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Switching should not be driven by price alone clinical suitability, tolerability and patient preference remain paramount
Endotoxin is the underreported risk
In SUSTAIN-6, use of once-weekly semaglutide led to an increased risk of diabetic retinopathy worsening (HR 176, 95% CI 111 276) [1], and it has been speculated that this can likely be attributed to early worsening given the rapid improvement in glycemic control in the semaglutide arm [21]
Common combinations that create confusion: Semaglutide + insulin: Insulin units ARE standardized (1 unit = a fixed biological activity)
Stick to once-weekly injections as prescribed
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