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And FOXO4-DRI selectively induced apoptosis of senescent keloid cells at the same clearance efficiency as in normal skin fibroblasts
This is based on its 6 to 8 day half-life and the pharmacological principle that 4 to 5 half-lives are required for near-complete elimination
Their main characteristics are shown in Fig
Patients should promptly report any severe symptoms or unusual side effects to their healthcare provider
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For instance, topical applications often require higher concentrations at the site of action compared to injected methods, which bypass first-pass metabolism
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