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Gut symptoms often show first improvements within 2 to 4 weeks, while tendon and ligament changes usually begin around 3 to 4 weeks after a protocol that had stalled in physical therapy

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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

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