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Mice were randomly assigned to treatment and control groups

Histol Histopathol

Hepatology 64(6):20282037 Wachsmuth HR, Weninger SN, Duca FA (2022) Role of the gutbrain axis in energy and glucose metabolism

Therefore, some of these findings would corroborate that UA may be a modifiable factor in the progression of chronic kidney disease, without sufficient data to state whether the beneficial effect of allopurinol is due to the reduction of UA or to the antioxidant effect produced by inhibiting the xanthine oxidase enzyme, however, the two large randomized clinical trials do not offer positive results so there is insufficient evidence to recommend allopurinol treatment in patients with asymptomatic hyperuricemia