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Thus, results from multivariate analyses of large datasets do not provide a valid basis for asserting that early exposure to APAP might be safe for neurodevelopment.The first study to indicate that pediatric use of APAP is associated with ASD was a survey-based, case-controlled study published by Schultz et al

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Logistic regression analysis showed that exposure to either paracetamol or ibuprofen was associated with higher odds of developing moderate-to-severe BPD, and this association remained significant after correcting for potential confounders

Consequently, future analyses involving a larger study population may be warranted