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Abstract Carnitine is mainly biosynthesized in the liver and kidneys, so carnitine deficiency has occurred when liver tissue is damaged by liver diseases such as cirrhosis and non-alcoholic fatty liver disease (NAFLD), although blood free carnitine is high in most cases

Post hoc analysis of LEADER data revealed a persistent increase in the overall risk of biliary tract-related events and gallbladder diseases, consistently observed across four categories: uncomplicated gallbladder stones, complicated gallbladder stones, cholecystitis with/without gallbladder stones, and biliary obstruction [34]

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