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It was investigated under phase II clinical trials for the treatment of lipodystrophy, but the death of one participant put the trial to a halt
Carli M, Ferrari A, Mattke A, Zanetti I, Casanova M, Bisogno G, et al
Ross, D.A
Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology Importantly, imaging and metabolic studies consistently show that reductions in cerebral glucose metabolism and perfusion precede cognitive symptoms by years, often decades [8]
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