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This expansion is especially important because emerging observational evidence has already shown that GLP-1 receptor agonist exposure may be associated not only with altered symptom trajectories, but also with differences in major joint injections and conversion to arthroplasty in patients with preexisting OA, underscoring the need for future trials to capture pathway-level outcomes rather than pain alone (Porto et al., 2025)

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Sexual experience confers resilience to restraint stress in female rats