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These findings suggest that while bitter substances promise to improve glucose homeostasis, their potential adverse effects beyond the gastrointestinal system warrant careful consideration [196]

141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2

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GHK stands for glycine, histidine, and lysine, and Cu means the peptide is paired with a copper ion, which shifts how it behaves in tissue

10.1016/s0305-4179(03)00203-1 93 RaoK