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Drucker DJ, Sherman SI, Gorelick FS, Bergenstal RM, Sherwin RS, Buse JB

the lack of GIP responsivity has been ascribed to hyperglycaemia-associated switching of G protein signalling in beta cells [48]

However, clinical evidence of GIP receptor engagement is still lacking and due to similar actions of GIP and GLP-1 receptor activation, the distinct mode of action for this dual-acting compound is complex to address (41)

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