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For patients who've failed multiple biologics, developed neutralizing antibodies, or can't tolerate systemic immunosuppression, peptides represent a mechanistically distinct option

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As of 2026, no peer-reviewed human clinical trials on FOXO4-DRI have been published

This ability further enhances its therapeutic value in treating conditions characterized by tissue injury or dysfunction

This work was supported by the National Cancer Institute through the Cancer Center Support Grant P30CA16672 (Institutional Tissue Bank (ITB) and Research Histology Core Laboratory (RHCL)) and supported by the generous philanthropic contributions to The University of Texas MD Anderson Cancer Center Moon Shots Program, Adaptive Patient-Oriented Longitudinal Learning and Optimization (APOLLO) Moonshot Program, and the Translational Molecular Pathology-Immunoprofiling (TMP-IL) Platform at the Department Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center