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Incretin effect after oral amino acid ingestion in humans
In the brain, GLP-1s reduce appetite and cravings (the fundamental mechanism of addictive disease)
If you experience new or worsening digestive side effects such as nausea, stomach discomfort, or heartburn, or more serious signs like unusual bleeding, black/tarry stools, or severe abdominal pain, you should stop taking ibuprofen and contact your healthcare provider immediately
Proceedings of the National Academy of Sciences of the United States of America , 89 , 86418645 (United States, 1992)
Many patients reduce their dose or quit entirely because of GI discomfort
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