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Why Patients Switch Common reasons to switch from Trulicity to Ozempic: Inadequate blood sugar control despite maximum Trulicity dose Desire for greater weight loss Wanting to try the more potent option Insurance change favoring Ozempic Access to compounded semaglutide Common reasons to switch from Ozempic to Trulicity: Insurance change favoring Trulicity Intolerable side effects on Ozempic (trying alternative) Device preference Provider recommendation How to Switch From Trulicity to Ozempic: Stop Trulicity (no taper needed) Begin Ozempic at starting dose (0.25mg) Follow standard titration schedule Can start Ozempic the week after last Trulicity dose From Ozempic to Trulicity: Stop Ozempic (no taper needed) Begin Trulicity at appropriate dose Provider may start at maintenance dose given GLP-1 experience Can start Trulicity the week after last Ozempic dose What to Expect When Switching Transitioning to Ozempic: GI side effects may recur during titration even if tolerating Trulicity Full Ozempic effect takes several weeks to months (titration period) Greater appetite suppression and potential weight loss as reaching higher doses Some providers use accelerated titration for patients switching from other GLP-1s Transitioning to Trulicity: Similar GI adjustment period possible May notice less appetite suppression compared to Ozempic Blood sugar may change during transition

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Available online at: (Accessed June 1, 2025)

GEP44, GEP12 is less potent than GEP44 when administered in vivo to reduce food intake and body weight (and is much more unstable to aggregation in aqueous solution)

However, the clinical precedent from switching between other GLP-1 medications provides some guidance