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Safety Profiles and Potential Side Effects Understanding the safety profiles and potential side effects of any compound is paramount before considering its use, especially when addressing the question of "NAD+ and AOD9604 which should one take and what about combining." NAD+ Precursors (NMN/NR) Safety and Side Effects NAD+ precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are generally considered safe and well-tolerated in human studies at recommended doses

By downregulating NNMT activity, research shows 5Amino1MQ may support increased NAD availability, enhanced mitochondrial function, and improved metabolic efficiency

Still, side effects from B12 supplements are possible, especially at higher doses, and include: Headache Nausea Vomiting Fatigue Weakness Diarrhea Tingling in the hands and feet Nasal spray Vitamin B12 is also available in a nasal spray

It is not FDA-approved, and this page covers research evidence rather than human-use guidance
