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Beyond those exclusions, it lists gastrointestinal side effects, dehydration risk, and thyroid concerns in specific populations as considerations

GLP-1/GLP-1R signaling regulates ovarian PCOS-associated granulosa cells proliferation and antiapoptosis by modification of forkhead box protein O1 phosphorylation sites

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However, subsequently, in a trial that I led of nearly 19,000 participants in 42 countries around the world, there was a significant excess of depression, neuropsychiatric side-effects and suicidal ideation which spelled the end of that drugs life

Prevention strategies include maintaining adequate protein intake (minimum 80-100g daily), taking biotin supplements (2,500-5,000mcg daily), avoiding crash dieting on top of medication effects, and ensuring sufficient iron and zinc intake