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Starting low and titrating up remains the safest approach
Tong J, Hannan F, Zhu Y, Bernards A, Zhong Y
Although the effect of mB12/LDFA and BH4 on methylation and glutathione metabolism have been examined in the open-label studies, these changes have not been compared to controls who received a placebo in order to account for the natural variation in the changes in these pathways
First subtle improvements at months 2 to 3, most visible changes at months 4 to 6
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