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Glyoxalase II (EC 3.1.2.6) catalyzes the hydrolysis of S -D-lactoylglutathione to glutathione and D-lactic acid

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Furthermore, GSTP1-1 has also been shown to bind and inhibit tumor necrosis factor receptor-associated factor 2 (TRAF2), an upstream activator of JNK, thus blocking the MAPK/JNK signaling cascade at multiple levels 29