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In the meantime, we must be realistic about the long-term possibility of negative consequences from semaglutide and approach its prescription and use with a commensurate level of caution, taking into account the availability of alternative approaches such as bariatric surgery

manageable with dietary adjustments Nausea, diarrhoea, constipation, and vomiting are the most commonly reported side effects and can be disruptive in the early weeks Dosing convenience Once-weekly injection using a simple, discreet auto-injector pen

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These findings suggest that once-weekly subcutaneous semaglutide, when combined with lifestyle interventions, offers superior weight loss benefits in individuals with overweight or obesity compared to once-daily subcutaneous liraglutide [10]