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doi: 10.1016/j.isci.2024.109784 Roland BC, Lee D, Miller LS, Vegesna A, Yolken R, Severance E, et al
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GLP-1R activity also promotes the transactivation of epidermal growth factor receptor (EGFR), which then signals through phosphoinositide 3-kinase (PI3K) and insulin receptor substrate-2 (IRS-2), and subsequently activates extracellular-signal-regulated kinase 1 and 2 (ERK1/2) and nuclear translocation of PKC to mediate -cell proliferation and differentiation (110, 114)
doi: 10.1210/endrev/bnad013
Retatrutide has not been approved by Health Canada or the FDA for weight management
