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CAT and SOD activities have been widely studied in VPA-induced autism models, but antioxidant responses appear to vary according to tissue, brain region, developmental stage, and experimental conditions

KL assisted in conducting in vitro experiments and acquiring data

Interestingly, Chac1 expression is decreased in livers of patients with MASLD, highlighting its potential therapeutic relevance

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However, this practice inevitably narrows the clinical spectrum represented in research samples and reduces natural heterogeneity of ASD, limiting the generalizability of findings