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Additionally, the other main compounds were 9,12-Octadecadienoic acid, methyl ester, (E, E) (8.30%), 9-Octadecenoic acid (Z)-, methyl ester (6.58%), palmitic Acid, TMS derivative (5.56%), Hexadecanoic acid, methyl ester (4,08%), and phytol acetate (3.08%), ( Fig
To date, eight different variants, including three frameshift mutations (37.5%), two missense mutations (25.0%), one nonsense mutation (12.5%), one copy number mutation (12.5%), and one six-base in-frame deletion (12.5%), have been reported in China in 10 patients from nine unrelated families (Table 1)
Preclinical evidence indicates that restoring MQC function via the activation of mitophagy may reduce mtDNA release and inhibit pyroptosis, a strategy that has been proposed as a potential therapeutic target for OA
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