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[172] [173] A 2026 systematic review on ADHD medication tolerance found evidence of tolerance developing to some affective state effects of amphetamine (e.g., positive mood and drug liking) within two weeks of daily use, but little to no evidence of long-term tolerance to its therapeutic or cardiovascular effects

Athletes or those with active lifestyles can also benefit from improved recovery and reduced inflammation

The implication for clinical practice is that restoring youthful MOTS-c signaling might be a mechanistically legitimate target for longevity intervention

A morphometric analysis of prefrontal area 9 and occipital area 17

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