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Steric hindrance is the major limiting factor in the synthesis of the B 12 coenzyme analogs
High oral bioavailability and membrane permeability ensure effective systemic distribution without complex preparation requirements
You may not get enough B12 in your diet if you are: Vegan Vegetarian Over 50 Living with digestive conditions that affect nutrient absorption, such as IBS, celiac, or Crohns disease Taking certain medications like metformin or proton pump inhibitors (PPIs) What are the symptoms of B12 deficiency
Vitamin B12 is essential for energy, brain function, and overall health, yet many people struggle with deficiencies that can leave them feeling fatigued and sluggish
(2013) Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial
