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The SURMOUNT-5 trial provides definitive evidence that Tirzepatide's dual GIP/GLP-1 receptor agonist mechanism translates into superior weight loss efficacy compared to a selective GLP-1 RA, even at its highest approved dose for obesity
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29 By contrast, in a study of Liraglutide for weight reduction (in people with type 2 diabetes) participants lost about 6 percent of their body weight, depending on dose
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