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Figure 2 4 Pathogenesis and tumor microenvironment Breast cancer is an ecosystem that contains both malignant cells and stromal cells and are characterized by a substantial change in the surrounding stroma, or TME, essential for cancer growth and progression

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In some embodiments, the flow rate of the first purification is about 4.7 mL/min, when the column has a diameter and length of 10 mm 250 mm