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Further, low dose sodium selenite supplementation prevented the radiation-induced DNA damage in peripheral leukocytes but could not increase the 30-day survival of mice

10.1080/01926230701320337 60 El-SayedN

Further studies involving robust mechanistic validation, pharmacokinetic profiling, and clinical translation are essential to determine whether these compounds possess genuine therapeutic potential or if their effects are limited to experimental settings

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However, under cellular conditions, the concentration (110 mM) of GSH is several folds higher than of hydroperoxides (10100 M), and thus, the velocity ( V max ) of the detoxification of hydroperoxides by seleno-GPxs is practically independent of the concentration of GSH [8, 17, 18]