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That does not invalidate DSIPs use as a subcutaneously injected peptide, but it changes the degree of certainty you should expect with the results you get

Efficacy and safety of once-weekly cagrilintidesemaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study, The Lancet Diabetes & Endocrinology, 14 , 8, (649-661), (2026)

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