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It was developed as a pharmaceutical drug and one small clinical trial was filed but it was canceled

The higher P53 level in breast cancer cells restricts the binding of free Keap1 to free Nrf2

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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]