semaglutide for prediabetes TrimRX obesity #prediabetes #type2diabetes #endocrinology #metabolichealth

S.et al (2025)

In their paper on the study, published in JAMA Ophthalmology , the researchers noted that the substantially increased risk of NAION observed in patients on semaglutide appears not to be due to differences in baseline characteristics between the cohorts. They proposed the possibility that expression of the GLP-1 receptor in the human optic nerve and GLP-1 RA-induced enhanced sympathetic nervous system activity might influence optic nerve head perfusion and potentially increase the risk of NAION. Another notable finding was that the greatest risk of NAION appeared to be within the first year following the prescription of semaglutide, a temporal association that supports a potential drug-induced risk of NAION, the researchers pointed out

The synthesis of endogenous glutathione occurs in a tightly regulated, two-step enzymatic process

Mouth Pain and Inflammation A deficiency of vitamin B12 or other nutrients can cause inflammation and pain of the tongue (the medical term is glossitis)

A gradual taper reducing dose by 2550% every 24 weeks lets your brain and gut adjust