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E2, 17-estradiol
500 mg daily is within standard supplementation ranges and generally considered safe for most healthy adults with normal liver function
Its well-established roles are antioxidant defense, hepatic detoxification, and immune support
Many users report that the benefits become more noticeable the longer they use it consistently
In addition, because the study of long-term high-intensity CR in humans is very limited, CR drugs and compounds that can replace CR have also received attention in recent years, such as metformin and rapamycin, but they will also produce inevitable toxic side effects
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