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Since the fourth decade of life, skeletal muscle undergoes a progressive decline in cross-sectional area, attributed to reductions in both fiber size and number [4,5,6]

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The mechanism appears to involve tyrosinase activity, oxidative stress, and toxic metabolites that place melanocytes under severe pressure

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Long-chain acylcarnitines activate cell stress and myokine release in C2C12 myotubes: calcium-dependent and -independent effects