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Reducing agents are the other hazard, because reduction of the metal changes its coordination preferences and can release it from the complex, and thiol reagents of the kind routinely present in cell-biology buffers both reduce and chelate

These five steps eliminate most injection site reactions

Room temperature represents just one option on a spectrum from frozen storage to elevated temperature stress

The dose itself might not change dramatically from the systemic protocol (e.g., 250-350mcg total per day), but the location of the administration is the key variable

10.1016/0024-3205(94)00796-9 119 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.JagicV.et al (1997c)