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doi: 10.1016/j.ejmech.2017.07.030 158 HomaM.HegedsK.Flp.WolfrtV.KadaikunnanS.KhaledJ
Used together under supervision, they aim to support a more natural release pattern
Nasal spray considerations: Typically lower bioavailability than injection, requiring somewhat higher doses Faster onset in some users due to direct CNS access More convenient and less intimidating for needle-averse individuals Requires properly calibrated spray bottles for accurate dosing Converting from injectable to nasal dosing is not straightforward
Injection site reactions, weight gain, and hypoglycemia dominate the side effect profile
There also would be interest in undertaking studies with GLP-1RAs such as semaglutide, designed to establish their effect on retardation of the atherosclerosis process along the lines of the studies carried out with pioglitazone, 1-3,12,13 which demonstrated slowing of the progression of carotid artery intimamedia thickness 15 and coronary artery atheroma
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